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breathing apparatus, and cartridge respirators may also be appropriate for spill response preparedness, depending on the physical properties and toxicity of the materials being used (see section 6.C.2.4). Before the experiment begins, prepare an experiment plan that describes the additional safeguards that will be used for all phases of the experiment from acquisition of the chemical to its final safe disposal. The amounts of materials used and the names of the people involved should be included in the written summary and recorded in the laboratory notebook. Individuals who work with highly toxic chemicals, as identified in Chapter 4 (see section 4.C, Tables 4.1, 4.2, and 4.3), should be thoroughly familiar with the general guidelines for the safe handling of chemicals in laboratories (see section 6.C). They should also have acquired through training and experience the knowledge, skill, and discipline to carry out safe laboratory practices consistently. However, these guidelines alone are not sufficient when handling substances that are known to be highly toxic and chemicals that, when combined in an experimental reaction, may generate highly toxic substances or produce new substances with the potential for high toxicity. Additional precautions are needed to set

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