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Strategies: Thirty‐5 sufferers with MDD and 343 healthy subjects were recruited. Unlike the melancholy trait, the hypomania trait is associated solely with bipolar disorder, and, as such, we recommend that a stronger post‐illumination pupillary response to blue light could be a particular biomarker for circadian rhythm disruption in bipolar dysfunction. Introduction: Circadian rhythm disruption is frequent in bipolar disorder and will even be present prior to the

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